Police were called by the ambulance service at 6.39am to reports of a collision between a silver Nissan Note and a black Yamaha motorcycle on the A327 Reading Road, Finchampstead, near to the clay pits.
The motorcyclist, a 27-year-old man from Reading, was taken to hospital by ambulance but was pronounced dead on route.
The driver of the Nissan, a 33-year-old man from Hampshire, was arrested on suspicion of causing death by dangerous driving and is currently in police custody.
The road remains closed in both directions while collision investigators examine the scene. Motorists are advised to avoid the area.
Anyone who witnessed the collision or saw either vehicle before it should contact Investigator Harry Wilkinson at the Road Death Investigation Unit via the Police Enquiry Centre on 101.
If you don't want to speak directly to the police you can contact the independent charity Crimestoppers anonymously on 0800 555 111 or online at www.crimestoppers-uk.org. No personal details are taken, information is not traced or recorded and you will not go to court.