A 41-year-old-man and a 62-year-old woman were arrested at separate addresses on a caravan site in Billingbear.
About £20,000 was seized from the sites as part of Operation Raglan.
A total of 17 warrants were executed across the Thames Valley on Wednesday morning.
Det Supt David Poole, Head of the Serious and Organised Crime Unit (SOCU), said: "Today's arrests come as a result of an intelligence led operation into those who commit crime and those who benefit from it.
"As a result of this operation, 14 people are in custody and we have seized suspected criminal cash and, drugs. Taking cash away from those involved in criminality reduces crime and acts as a deterrent to others.
"The clear message this operation sends to criminals is not to commit crime or we will arrest you and take your cash.
"Operations such as this need intelligence and information from our communities and I would like to thank those who have supplied information which has fed into this investigation. If you suspect someone is living a lavish lifestyle off the proceeds of crime, report your suspicions to the police or Crimestoppers. We will act upon it and prove crime doesn't pay."