Arborfield Road, which connects Arborfield to Shinfield, was closed after a car collided with a traffic sign.
A man had to be cut out of the car by fire fighters, using specialist hydraulic equipment, and was taken to hospital.
No other casualties were reported.
The crash happened around 11am at Arborfield Bridge, and was described as a ‘serious’.
A single lane was opened earlier - with traffic control measures in place - as the vehicle was recovered from the scene.
All three emergency services, including firefighters from Whitley Wood and Wokingham Road attended the scene.