A diversion route via the A308 Windsor Road will be clearly signed.
The work, which started on Wednesday night, is part of a project to repair sections of the road surface.
Additionally, on Saturday night from the same times, there will be a closure on the westbound carriageway within junction 8/9 with a diversion across the junction interchange.
On Sunday night during the same time period, the westbound entry slip road at junction 8/9 will be closed with a diversion in place via junction 6.
All restrictions will be removed outside working hours.